Quran 37:110 · As-Saffat

In the days of Abraham, polytheism was so dominant that its continuity in history had been long established. Now, any child born into this situation was influenced by the surrounding atmosphere and was so immersed in polytheism that no effort even at the level of the Prophet was successful in weaning him away from it. When Abraham left Iraq, after a long missionary struggle, there were only two believers with him—one his wife Sarah and the other his nephew, Lot. People did not adhere to the concept of the oneness of God, despite the utmost struggle on the part of Prophet Abaraham. So, Almighty God planned that a new race be brought into existence which should be nurtured far away from the atmosphere of polytheism. For this purpose, the area of Hijaz was selected. This area, being dry and without any vegetation, was desolate and uninhabited. The plan was that a devotee should be settled in this area where he would become the progenitor of a pure race. Hijaz (Mecca and Medina) was a waterless desert and to settle anyone in such arid surroundings amounted to sacrificing him alive. God ordered Abraham to offer his son Ishmael as a sacrifice, and in all obedience, Abraham submitted to God’s will. Abraham’s second son was Isaac. Prophethood continued in his line of descent until the advent of the last prophet who belonged to the Children of Ishmael (the younger brother of Isaac). The Prophet Muhammad brought about a revolution, which destroyed polytheism as a dominant school of thought.